The isolated hepatocyte use in toxicology and xenobiotic biotransformations book o 1987 search in this book search in this book browse content table of contents select all front matter full text access cell biology a series of monographs front matter toxicology studies in cultured hepatocytes from various species charlene a . The isolated hepatocyte use in toxicology and xenobiotic transformation edited by e j rauckman and g m padilla academic press 1987 7500 viii 292 pages isbn 0 12 582870 5. Note citations are based on reference standards however formatting rules can vary widely between applications and fields of interest or study the specific requirements or preferences of your reviewing publisher classroom teacher institution or organization should be applied. Problems in the use of isolated hepatocytes on first consideration isolated and cultured hep atocytes would seem to be ideal for the study of hepatic xenobiotic metabolism and metabolism based hepatotoxicity there is no problem with inter ference from other tissues the exact concentration of compound reaching the cells can be accurately . Cells were cultured on microcarriers for up to 48 hr and retained 25 of the initial eod activity that was seen in freshly isolated liver cells microcarrier attached hepatocytes were cocultured with balb c 3t3 cells to study the metabolism mediated cytotoxicity of cyclophosphamide cpa
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