Edited by the 1991 winners of the nobel prize in physiology or medicine this second edition includes new chapters covering such applications as capacitance measurements single cell pcr measurements whole cell recording from brain slices in combination with imaging techniques atomic force microscopy of cells and membranes attached to glass pipettes and patch clamping. Single channel recording has become a widely used tool for the study of ion permeation mechanisms in biological membranes whereas the technique might have been considered an art after its introduction in 1976 it developed into a relatively simple method after it became possible to obtain high resistance several gigaohm membrane pipette seals. The ability to record the real time movement of a protein is quite enthralling in effect this is what we achieve when we record the activity of an individual ion channel clearly we do not see. A single channel recording is a single molecule technique that measures the activity of a single membrane channel usually by means of a path pipette external links single channel recording second edition references. Single channel recording has 11 ratings and 2 reviews carolyn said known to electrophysiologists as the blue bible i now understand why this book ha
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