Tests to stage disease and treatment even if you have no symptoms hiv infection progresses to aids when your cd4 t cell count dips below 200 viral load hiv rna this test measures the amount of virus in your blood a higher viral load has been linked to a worse outcome non nucleoside reverse transcriptase inhibitors . Abstract the nucleoside reverse transcriptase inhibitors nrtis were the first class of compounds discovered to be potent inhibitors of hiv replication 1 and to date these drugs remain the backbone of antiretroviral therapynrtis are essentially prodrugs inactive in their parent form and requiring activation to exert their antiviral effects 2 3. Reverse transcriptase inhibitors rtis are a class of antiretroviral drugs used to treat hiv infection or aids and in some cases hepatitis b rtis inhibit activity of reverse transcriptase a viral dna polymerase that is required for replication of hiv and other retroviruses . The treatment is highly effective in slowing the rate at which the hiv virus replicates itself which may slow the spread of hiv in the body the goal of haart is to reduce the amount of virus in your body or the viral load to a level that can no longer be detected with blood tests non nucleoside reverse transcriptase inhibitors nnrti. Hiv reverse transcriptase is a heterodimer composed of 2 subunits p66 and p51ref27 nnrtis bind the p66 subunit at a hydrophobic pocket distant from the active site of the enzyme this
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