Drug design is an interdisciplinary art this text illustrates the pathway followed from the initial design concept and synthesis of an inhibitor through its in vitro and in vivo assessments to clinical trial a process involving chemists biochemists pharmacologists and clinicians. Enzyme inhibitors are used as tools for studying mechanisms of enzymatic catalysis and as compounds for treating certain physiologic disorders thus they remain prime targets for drug design because altering enzyme activity has immediate and defined effects their utility as mechanistic therapeutic . A high proportion of drugs currently coming to market exert their action in the body by inhibiting a target enzyme involved in a particular body function or in a bacterium protozoon or virus causing an infection design of enzyme inhibitors as drugs volume 2 edited by merton sandler and h john smith share also of interest better than . Structure based design table 1 gives an overview of recent applications of these techniques in the rational design of enzyme inhibitors and other protein ligands including some examples of structure based design without knowledge of the protein 3d structure compare with the later section on drug design based on ligand 3d structures
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